PD-L1/CD274 Recombinant antibody, PBS Only

PD-L1/CD274 Uni-rAbTM Recombinant Antibody for IHC, Indirect ELISA
Cat No. 82719-13-PBS

产品说明书

CloneNo. 3G4

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

IHC, Indirect ELISA

CD274, PD-L1, PD L1, hPD-L1, B7-H1

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -


产品信息

82719-13-PBS targets PD-L1/CD274 in IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原 PD-L1/CD274 fusion protein Ag12432 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 CD274 molecule
别名 CD274, PD-L1, PD L1, hPD-L1, B7-H1
计算分子量 290 aa, 33 kDa
GenBank蛋白编号BC074984
基因名称 PD-L1
Gene ID (NCBI) 29126
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDQ9NZQ7
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Programmed cell death ligand 1 (PD-L1, CD274, or B7-H1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. PD-L1 is suggested as a negative regulator of T and B cell, and plays important role in mediating tolerance of lymphocytes to self-antigens. It is also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PD-1-independent manner. PD-L1 is a 290 aa transmembrane protein with a calculated molecular weight of 33 kDa, it is predicted to be 27-30 kDa after signal peptide cleavage (PMID: 25609200; 17076679). The apparent molecular weight has also been reported as 45-70 kDa, major glycosylated form of 45-50 kDa and multiple post-translational modifications form of 65-70 kDa (PMID: 18760278; 16493058).

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