验证数据展示
产品信息
66554-1-PBS targets Serpin F1/PEDF in WB, Indirect ELISA applications and shows reactivity with human, pig samples.
经测试应用 | WB, Indirect ELISA Application Description |
经测试反应性 | human, pig |
免疫原 | Serpin F1/PEDF fusion protein Ag26660 种属同源性预测 |
宿主/亚型 | Mouse / IgG1 |
抗体类别 | Monoclonal |
产品类型 | Antibody |
全称 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 |
别名 | PIG35, PEDF, EPC-1, EPC 1, Cell proliferation-inducing gene 35 protein |
计算分子量 | 418 aa, 46 kDa |
观测分子量 | 46-50 kDa |
GenBank蛋白编号 | BC013984 |
基因名称 | PEDF |
Gene ID (NCBI) | 5176 |
RRID | AB_2881916 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purification |
UNIPROT ID | P36955 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
PEDF also known as serpin F1 (SERPINF1), is a multifunctional secreted protein that has anti-angiogenic, anti-tumorigenic, and neurotrophic functionsis. It is an approximately 50-kDa secreted protein that is widely expressed, including by osteoblasts and osteoclasts. PEDF is also one of the most abundant secretory products of adipocytes, and circulating concentrations of PEDF correlate positively with body fat mass and INS resistance. PEDF is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells. Mutations in this gene were found in individuals with osteogenesis imperfecta, type VI.