验证数据展示
产品信息
16826-1-PBS targets PIK3IP1 in WB, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Applications | WB, IP, Indirect ELISA Application Description |
| Tested Reactivity | human, mouse, rat |
| Immunogen | PIK3IP1 fusion protein Ag10427 种属同源性预测 |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Full Name | phosphoinositide-3-kinase interacting protein 1 |
| Synonyms | |
| Calculated Molecular Weight | 263 aa, 28 kDa |
| Observed Molecular Weight | 37 kDa |
| GenBank Accession Number | BC011049 |
| Gene Symbol | PIK3IP1 |
| Gene ID (NCBI) | 113791 |
| RRID | AB_2163333 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q96FE7 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
PIK3IP1(Phosphoinositide-3-kinase-interacting protein 1) is also named as HGFL. The class IA phosphoinositol-3-kinases (PI3Ks) regulate important cellular processes such as proliferation, growth, survival, motility and metabolism. PIK3IP1 is a transmembrane protein that possesses a region in its intracellular domain that shares homology with the p85 regulatory subunit of PI3K. It has 5 isoforms produced by alternative splicing with the MW of 11, 18, 19, 25,28 kDa. PIK3IP1 undergoes N- and O-linked amino acid glycosylation. The major glycosylated form of PIK3IP1 migrates at about 43 kDa in western blot analysis, while the unglycosylated form migrates at 37 kDa. It is also detected a 65 kDa variant in HepG2 cell lysate that PIK3IP1 is indeed membrane bound and that these variants arise from alternative splicing and/or post-translational processing events such as enzymatic proteolysis and/or glycosylation. (PMID:18632611).
