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  • Featured Product
  • KD/KO Validated

PJA1 Polyclonal antibody, PBS Only

PJA1 Polyclonal Antibody for WB, IP, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IP, Indirect ELISA

Conjugate

Unconjugated

Cat no : 17687-1-PBS

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Synonyms

验证数据展示

  • WB analysis of mouse brain using 17687-1-AP (same clone as 17687-1-PBS)

    WB analysis of mouse brain using 17687-1-AP (same clone as 17687-1-PBS)

    mouse brain tissue were subjected to SDS PAGE followed by western blot with 17687-1-AP (PJA1 antibody) at dilution of 1:200 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17687-1-PBS in a different storage buffer formulation.

  • IP experiment of mouse brain using 17687-1-AP (same clone as 17687-1-PBS)

    IP experiment of mouse brain using 17687-1-AP (same clone as 17687-1-PBS)

    IP result of anti-PJA1 (IP:17687-1-AP, 3ug; Detection:17687-1-AP 1:300) with mouse brain tissue lysate 3600ug. This data was developed using the same antibody clone with 17687-1-PBS in a different storage buffer formulation.

产品信息

17687-1-PBS targets PJA1 in WB, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Applications WB, IP, Indirect ELISA Application Description
Tested Reactivity human, mouse, rat
Immunogen PJA1 fusion protein Ag11820 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name praja ring finger 1
Synonyms
Calculated Molecular Weight 643 aa, 71 kDa
Observed Molecular Weight 71-80 kDa
GenBank Accession NumberBC075803
Gene Symbol PJA1
Gene ID (NCBI) 64219
RRIDAB_2252483
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ8NG27
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

PJA1(E3 ubiquitin-protein ligase Praja-1), also named as RNF70, regulates the level of PRC2 (polycomb repressive complex 2) by targeting its free subunits for Ub-mediated proteasomal degradation and it can be involved in protein ubiquitination in the brain and is a suitable candidate gene for MRX(PMID:12036302). The Praja1 protein is unlikely to be a membrane receptor, since it lacks a hydrophobic transmembrane domain(PMID:9393880). It has 3 isoforms produced by alternative splicing with the molecular weight of 71 kDa, 50 kDa and 65 kDa.