验证数据展示
产品信息
17687-1-PBS targets PJA1 in WB, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
经测试应用 | WB, IP, Indirect ELISA Application Description |
经测试反应性 | human, mouse, rat |
免疫原 | PJA1 fusion protein Ag11820 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Polyclonal |
产品类型 | Antibody |
全称 | praja ring finger 1 |
别名 | |
计算分子量 | 643 aa, 71 kDa |
观测分子量 | 71-80 kDa |
GenBank蛋白编号 | BC075803 |
基因名称 | PJA1 |
Gene ID (NCBI) | 64219 |
RRID | AB_2252483 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Antigen affinity purification |
UNIPROT ID | Q8NG27 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
PJA1(E3 ubiquitin-protein ligase Praja-1), also named as RNF70, regulates the level of PRC2 (polycomb repressive complex 2) by targeting its free subunits for Ub-mediated proteasomal degradation and it can be involved in protein ubiquitination in the brain and is a suitable candidate gene for MRX(PMID:12036302). The Praja1 protein is unlikely to be a membrane receptor, since it lacks a hydrophobic transmembrane domain(PMID:9393880). It has 3 isoforms produced by alternative splicing with the molecular weight of 71 kDa, 50 kDa and 65 kDa.