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PKMYT1 Monoclonal antibody, PBS Only

PKMYT1 Monoclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 67806-1-PBS

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CloneNo. 1D12D3

Host / Isotype

Mouse / IgG2a

Reactivity

Human, mouse, rat

Applications

WB, IHC, Indirect ELISA

DKFZp547K1610, FLJ20093, MYT1, Myt1 kinase, PKMYT1

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size: 

-/ -


产品信息

67806-1-PBS targets PKMYT1 in WB, IHC, Indirect ELISA applications and shows reactivity with Human, mouse, rat samples.

Tested Applications WB, IHC, Indirect ELISA Application Description
Tested Reactivity Human, mouse, rat
Immunogen PKMYT1 fusion protein Ag30849 种属同源性预测
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Full Name protein kinase, membrane associated tyrosine/threonine 1
Synonyms DKFZp547K1610, FLJ20093, MYT1, Myt1 kinase, PKMYT1
Calculated Molecular Weight 55 kDa
Observed Molecular Weight 55 kDa
GenBank Accession NumberNM_004203
Gene Symbol PKMYT1
Gene ID (NCBI) 9088
RRIDAB_2918569
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ99640
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Protein kinase, membrane associated tyrosine/threonine (PKMYT1) is a member of the Wee family of protein kinases. PKMYT1 acts as a negative regulator of the cell cycle by inactivating the CDK1-cyclinB complex through phosphorylation of Tyr14/Tyr15 and preventing cell cycle entering into mitosis at the G2/M transition. In mammalian somatic cells, PKMYT1 affects the assembly of the Golgi apparatus and endoplasmic reticulum during telophase of mitosis by inhibiting cyclin activities. Abnormal expression of PKMYT1 is closely associated with multiple types of cancers. PKMYT1 protein was mainly localized in the cytoplasm. (PMID: 31695486, PMID: 32801781)

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