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Host
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Species Reactivity
0
Species Reactivity
0
Conjugate
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验证数据展示

  • WB analysis using 84604-4-RR (same clone as 84604-4-PBS)

    WB analysis using 84604-4-RR (same clone as 84604-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84604-4-RR (PON3 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84604-4-PBS in a different storage buffer formulation.

  • IHC staining of mouse liver using 84604-4-RR (same clone as 84604-4-PBS)

    IHC staining of mouse liver using 84604-4-RR (same clone as 84604-4-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 84604-4-RR (PON3 antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84604-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84604-4-RR

    Affinity and Kinetic Characterization of 84604-4-RR

    Biolayer interferometry (BLl) kinetic assays of 84604-4-RR against Human PON3 were performed. The affinity constant is below 1 pM.

PON3 Recombinant antibody, PBS Only

PON3 Uni-rAbTM Recombinant Antibody for WB, IHC, Indirect ELISA
Cat No. 84604-4-PBS

产品说明书

CloneNo. 242035D11

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, Indirect ELISA

别名

Paraoxonase 3 , Paraoxanase-3, EC:3.1.8.1, 242035D11

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

84604-4-PBS targets PON3 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原 PON3 fusion protein Ag36602 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 paraoxonase 3
别名 Paraoxonase 3 , Paraoxanase-3, EC:3.1.8.1, 242035D11
计算分子量NM_000940.2 40kDa，354aa
观测分子量40 kDa
GenBank蛋白编号NM_000940.2
基因名称 PON3
Gene ID (NCBI) 5446
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDQ15166
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

PON3, a member of the paraoxonase family, is expressed primarily in the liver and encodes a protein that is secreted into the bloodstream and binds to high-density lipoprotein (HDL). It also rapidly hydrolyzes lactones and inhibits the oxidation of low-density lipoprotein (LDL), thereby slowing the onset and progression of atherosclerosis. In addition, PON3 is closely associated with hepatocellular carcinoma (HCC), and is a potential therapeutic target for HCC by inducing cell cycle arrest and further inhibiting HCC cell proliferation.