PDP1 Recombinant antibody, PBS Only (Detector)

PDP1 Uni-rAbTM Recombinant Antibody for WB, Cytometric bead array, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, Cytometric bead array, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

242090E7

Cat no : 84612-3-PBS

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Synonyms

PPM2C, PDPC 1, PDP 1, EC:3.1.3.43, 242090E7



Planning an IHC experiment? We recommend our IHCeasy PDP1 Ready-To-Use IHC Kit. PDP1 primary antibody included.

产品信息

84612-3-PBS targets PDP1 as part of a matched antibody pair:

MP01450-2: 84612-1-PBS capture and 84612-3-PBS detection (validated in Cytometric bead array)

Unconjugated rabbit recombinant monoclonal antibody in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation. Created using Proteintech’s proprietary in-house recombinant technology. Recombinant production enables unrivalled batch-to-batch consistency, easy scale-up, and future security of supply.

This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.

Tested Applications WB, Cytometric bead array, Indirect ELISA Application Description
Tested Reactivity human, mouse
Immunogen PDP1 fusion protein Ag15453 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name protein phosphatase 2C, magnesium-dependent, catalytic subunit
Synonyms PPM2C, PDPC 1, PDP 1, EC:3.1.3.43, 242090E7
Calculated Molecular Weight 537 aa, 61 kDa
Observed Molecular Weight 55-61 kDa
GenBank Accession NumberBC047619
Gene Symbol PDP1
Gene ID (NCBI) 54704
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ9P0J1
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Pyruvate dehydrogenase phosphatase 1 (PDP1),also known as PPM2C, is a key hormone-regulated metabolic enzyme that dephosphorylates and activates pyruvate dehydrogenase (PDH), thereby stimulating the conversion of pyruvate into acetyl-CoA (PMID: 36453802). PDP1 expression is regulated by FLT3-ITD in a context-dependent manner, and that it is centrally involved in the adaptation of AML glucose metabolism to the requirements of proliferation, survival and the therapeutic response to FLT3 inhibition (PMID: 37935978).