验证数据展示
产品信息
67809-1-PBS targets PPP2CA in WB, IHC, Indirect ELISA applications and shows reactivity with Human, rat samples.
Tested Applications | WB, IHC, Indirect ELISA Application Description |
Tested Reactivity | Human, rat |
Immunogen | PPP2CA fusion protein Ag4294 种属同源性预测 |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Full Name | protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform |
Synonyms | PP2A alpha, PP2Ac, PP2CA, PPP2CA, Replication protein C, RP C |
Calculated Molecular Weight | 309 aa, 36 kDa |
Observed Molecular Weight | 33 kDa |
GenBank Accession Number | BC031696 |
Gene Symbol | PPP2CA |
Gene ID (NCBI) | 5515 |
RRID | AB_2918572 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein G purification |
UNIPROT ID | P67775 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
PPP2CA, also named as RP-C and PP2A-alpha, belongs to the PPP phosphatase family and PP-1 subfamily. PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. PP2A activity was modestly decreased in AML patients harboring C-KIT/WT.PP2A is a target for C-KIT/TKD and implicated the potential efficacy of therapies targeting PP2A in such AML in future.