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验证数据展示

  • IF Staining of A375 using 84767-4-RR (same clone as 84767-4-PBS)

    IF Staining of A375 using 84767-4-RR (same clone as 84767-4-PBS)

    Immunofluorescent analysis of (4% PFA) fixed A375 cells using PSMD14 antibody (84767-4-RR, Clone: 242160H6 ) at dilution of 1:250 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 84767-4-PBS in a different storage buffer formulation.

PSMD14/POH1 Recombinant antibody, PBS Only

PSMD14/POH1 Uni-rAbTM Recombinant Antibody for IF/ICC, Indirect ELISA
Cat No. 84767-4-PBS

产品说明书

CloneNo. 242160H6

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

IF/ICC, Indirect ELISA

别名

PSMD14, POH1, PAD1, EC:3.4.19.-, 26S proteasome-associated PAD1 homolog 1

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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Planning an IHC experiment? We recommend our IHCeasy PSMD14 Ready-To-Use IHC Kit. PSMD14 primary antibody included.

产品信息

84767-4-PBS targets PSMD14/POH1 in IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原 PSMD14/POH1 fusion protein Ag2694 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
别名 PSMD14, POH1, PAD1, EC:3.4.19.-, 26S proteasome-associated PAD1 homolog 1
计算分子量 35 kDa
GenBank蛋白编号BC009524
基因名称 PSMD14
Gene ID (NCBI) 10213
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDO00487
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The PSMD14 (POH1, also known as Rpn11/MPR1/S13/CepP1) protein is a metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. PSMD14 is highly expressed in the heart and skeletal muscle. In carcinoma cell lines. down-regulation of PSMD14 by siRNA transfection considerably impacted cell viability, causing cell arrest in the G0-G1 phase, ultimately leading to senescence.