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Species Reactivity
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验证数据展示

  • IHC staining of human lymphoma using 11783-1-AP (same clone as 11783-1-PBS)

    IHC staining of human lymphoma using 11783-1-AP (same clone as 11783-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lymphoma tissue slide using 11783-1-AP (PTPN22 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11783-1-PBS in a different storage buffer formulation.

  • WB analysis using 11783-1-AP (same clone as 11783-1-PBS)

    WB analysis using 11783-1-AP (same clone as 11783-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 11783-1-AP (PTPN22 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11783-1-PBS in a different storage buffer formulation.

  • IP experiment of Jurkat using 11783-1-AP (same clone as 11783-1-PBS)

    IP experiment of Jurkat using 11783-1-AP (same clone as 11783-1-PBS)

    IP result of anti-PTPN22 (IP:11783-1-AP, 4ug; Detection:11783-1-AP 1:300) with Jurkat cells lysate 3080ug. This data was developed using the same antibody clone with 11783-1-PBS in a different storage buffer formulation.

PTPN22 Polyclonal antibody, PBS Only

PTPN22 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 11783-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, IP, Indirect ELISA

别名

PEP, LYP2, LYP1, LyP, Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

11783-1-PBS targets PTPN22 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, IP, Indirect ELISA Application Description
经测试反应性 human
免疫原 PTPN22 fusion protein Ag2397 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
别名 PEP, LYP2, LYP1, LyP, Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
计算分子量 82 kDa, 92 kDa
观测分子量 100-110 kDa
GenBank蛋白编号BC017785
基因名称 PTPN22
Gene ID (NCBI) 26191
RRIDAB_2173378
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9Y2R2
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

PTPN22(Tyrosine-protein phosphatase non-receptor type 22) is also named as LyP,PEP,PTPN8.It belongs to the protein-tyrosine phosphatase family and non-receptor class 4 subfamily.It acts as negative regulator of T-cell receptor (TCR) signaling.Defects in PTPN22 are a cause of susceptibility to systemic lupus erythematosus (SLE). It has some isoforms produced by alternative splicing with calculated molecular mass of 79-92 kDa, and apparent molecular mass of 100-110 kDa.