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PTPN22 Polyclonal antibody, PBS Only

PTPN22 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, IP, Indirect ELISA

Conjugate

Unconjugated

Cat no : 11783-1-PBS

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Synonyms

验证数据展示

  • IHC staining of human lymphoma using 11783-1-AP (same clone as 11783-1-PBS)

    IHC staining of human lymphoma using 11783-1-AP (same clone as 11783-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lymphoma tissue slide using 11783-1-AP (PTPN22 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11783-1-PBS in a different storage buffer formulation.

  • WB analysis using 11783-1-AP (same clone as 11783-1-PBS)

    WB analysis using 11783-1-AP (same clone as 11783-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 11783-1-AP (PTPN22 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11783-1-PBS in a different storage buffer formulation.

  • IP experiment of Jurkat using 11783-1-AP (same clone as 11783-1-PBS)

    IP experiment of Jurkat using 11783-1-AP (same clone as 11783-1-PBS)

    IP result of anti-PTPN22 (IP:11783-1-AP, 4ug; Detection:11783-1-AP 1:300) with Jurkat cells lysate 3080ug. This data was developed using the same antibody clone with 11783-1-PBS in a different storage buffer formulation.

产品信息

11783-1-PBS targets PTPN22 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Applications WB, IHC, IP, Indirect ELISA Application Description
Tested Reactivity human, mouse, rat
Immunogen PTPN22 fusion protein Ag2397 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Synonyms
Calculated Molecular Weight 82 kDa, 92 kDa
Observed Molecular Weight 100-110 kDa
GenBank Accession NumberBC017785
Gene Symbol PTPN22
Gene ID (NCBI) 26191
RRIDAB_2173378
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ9Y2R2
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

PTPN22(Tyrosine-protein phosphatase non-receptor type 22) is also named as LyP,PEP,PTPN8.It belongs to the protein-tyrosine phosphatase family and non-receptor class 4 subfamily.It acts as negative regulator of T-cell receptor (TCR) signaling.Defects in PTPN22 are a cause of susceptibility to systemic lupus erythematosus (SLE). It has some isoforms produced by alternative splicing with calculated molecular mass of 79-92 kDa, and apparent molecular mass of 100-110 kDa.