Phospho-NF-κB p65 (Ser468) Recombinant antibody, PBS Only
Phospho-NF-κB p65 (Ser468) Recombinant Antibody for WB,Indirect ELISA
Host / Isotype
Rabbit / IgG
Reactivity
Human, Mouse
Applications
WB,Indirect ELISA
Conjugate
Unconjugated
CloneNo.
6N1
验证数据展示
Planning an IHC experiment? We recommend our IHCeasy NF-κB p65/RELA Ready-To-Use IHC Kit. NF-κB p65/RELA primary antibody included.
产品信息
82335-1-PBS targets Phospho-NF-κB p65 (Ser468) in WB, Indirect ELISA applications and shows reactivity with Human, Mouse samples.
| Tested Applications | WB,Indirect ELISA Application Description |
| Tested Reactivity | Human, Mouse |
| Immunogen | Peptide 种属同源性预测 |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Full Name | v-rel reticuloendotheliosis viral oncogene homolog A (avian) |
| Synonyms | NFKB3, p65, Phospho-NF-κB p65 (Ser468), RELA, Transcription factor p65 |
| Calculated Molecular Weight | 65 kDa |
| Observed Molecular Weight | 75 kDa |
| GenBank Accession Number | BC011603 |
| Gene Symbol | RELA |
| Gene ID (NCBI) | 5970 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | Q04206 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. |
背景介绍
Nuclear factor kB (NF-kB) is a collective term for a small family of dimeric transcription factors [comprising p65 (RelA) and RelB, c-Rel, p50/p105 (NF-κB1), and p52/p100 (NF-κB2)]. All NF-κB proteins share a Rel homology domain (RHD), which is responsible for DNA binding and dimerization. Only p65, RelB, and c-Rel contain potent transactivation domains within sequences from the C-terminal to the RHD. Exterior signals lead to the phosphorylation and degradation of the inhibitory complex IκB, which is modulated by the IκB kinase (IKK), and its degradation allows for the release of the typical NF-κB heterodimer, p65/p50, to translocate into the nucleus. NF-κB binds to its cognate DNA elements and can transcriptionally activate different target genes among which 200-500 genes have been implicated in cell survival/apoptosis, cell growth, immune response, and inflammation.