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Phospho-NTRK1 (Tyr496) Recombinant antibody, PBS Only

Phospho-NTRK1 (Tyr496) Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241917B1

Cat no : 84976-1-PBS

Print datasheet

Synonyms

NTRK1, Trk A, TRK, p140 TrkA, MTC

验证数据展示

  • WB analysis using 84976-1-RR (same clone as 84976-1-PBS)

    WB analysis using 84976-1-RR (same clone as 84976-1-PBS)

    Non-treated and pervanadate treated HeLa cells were subjected to SDS PAGE followed by western blot with 84976-1-RR (Phospho-NTRK1 (Tyr496) antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. The membrane was stripped and re-blotted with Vinculin (66305-1-Ig) antibody as a loading control. This data was developed using the same antibody clone with 84976-1-PBS in a different storage buffer formulation.

产品信息

84976-1-PBS targets Phospho-NTRK1 (Tyr496) in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity human
Immunogen Peptide 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name neurotrophic tyrosine kinase, receptor, type 1
Synonyms NTRK1, Trk A, TRK, p140 TrkA, MTC
Observed Molecular Weight140 kDa
GenBank Accession NumberBC062580
Gene Symbol NTRK1
Gene ID (NCBI) 4914
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDP04629
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The tyrosine kinase receptor TrkA (or neurotrophin receptor kinase 1, NTRK1) has been predominately studied for its role during the development of the nervous system. In developing neurons, TrkA activation upon binding of its ligands nerve growth factor (NGF) or neurotrophin-3 (NT-3) results in the stimulation of various tyrosine kinase-induced signaling pathways leading to neuronal outgrowth. (PMID: 32957504) This antibody recognizes the phosphorylation of TrkA at site 496, which is the phosphorylation of the isoform 2 sequence at site 490.