验证数据展示
产品信息
80199-2-PBS targets Phospho-STAT3 (Ser727) in WB, FC (Intra), Indirect ELISA applications and shows reactivity with human samples.
Tested Applications | WB, FC (Intra), Indirect ELISA Application Description |
Tested Reactivity | human |
Immunogen | Peptide 种属同源性预测 |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Full Name | signal transducer and activator of transcription 3 (acute-phase response factor) |
Synonyms | STAT3, STAT 3, HIES, APRF, Acute-phase response factor |
Calculated Molecular Weight | 770 aa, 88 kDa |
Observed Molecular Weight | 100 kDa |
GenBank Accession Number | BC000627 |
Gene Symbol | STAT3 |
Gene ID (NCBI) | 6774 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purfication |
UNIPROT ID | P40763 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3, synonyms: APRF, FLJ20882, MGC16063) is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT3 is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. STAT3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis.