Phospho-ULK1 (Ser556) Recombinant antibody, PBS Only
Phospho-ULK1 (Ser556) Recombinant Antibody for WB, Indirect ELISA
Host / Isotype
Rabbit / IgG
Reactivity
Human, mouse
Applications
WB, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
2F5
验证数据展示
This antibody is equivalent to Ser555 in mice.
Planning an IHC experiment? We recommend our IHCeasy ULK1 Ready-To-Use IHC Kit. ULK1 primary antibody included.
产品信息
80218-1-PBS targets Phospho-ULK1 (Ser556) in WB, Indirect ELISA applications and shows reactivity with Human, mouse samples.
| Tested Applications | WB, Indirect ELISA Application Description |
| Tested Reactivity | Human, mouse |
| Immunogen | Peptide 种属同源性预测 |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Full Name | unc-51-like kinase 1 (C. elegans) |
| Synonyms | ATG1, FLJ38455, FLJ46475, KIAA0722, Phospho-ULK1 (Ser556), ULK1, Unc 51 like kinase 1, UNC51, Unc51.1 |
| Observed Molecular Weight | 140 kDa |
| GenBank Accession Number | NM_003565 |
| Gene Symbol | ULK1 |
| Gene ID (NCBI) | 8408 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | O75385 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. |
背景介绍
Unc-51-like-kinase 1 (ULK1) is a target of both the mechanistic target of rapamycin (mTOR) and AMP activated protein kinase (AMPK), whose role is to facilitate the initiation of autophagy in response to starvation. ULK1 is phosphorylated on serine 638 and 758 sites by mTOR in nutrient-rich conditions, inhibiting ULK1 activation by disrupting its binding to AMPK. Upon glucose starvation, dissociation of mTOR from ULK1 and phosphorylation by AMPK leads to the activation of ULK1 activity. The S556 site of ULK1 is one of the major AMPK-dependent phosphorylation sites. (PMID: 30517873, PMID: 21258367)
