验证数据展示
产品信息
66944-1-PBS targets RAB27B in WB, IHC, IF/ICC, FC (Intra), Indirect ELISA applications and shows reactivity with human samples.
Tested Applications | WB, IHC, IF/ICC, FC (Intra), Indirect ELISA Application Description |
Tested Reactivity | human |
Immunogen | RAB27B fusion protein Ag18756 种属同源性预测 |
Host / Isotype | Mouse / IgG2a |
Class | Monoclonal |
Type | Antibody |
Full Name | RAB27B, member RAS oncogene family |
Synonyms | C25KG, Ras-related protein Rab-27B, Ras related protein Rab 27B, EC:3.6.5.2, 2B9G9 |
Calculated Molecular Weight | 218 aa, 25 kDa |
Observed Molecular Weight | 25 kDa |
GenBank Accession Number | BC027474 |
Gene Symbol | RAB27B |
Gene ID (NCBI) | 5874 |
RRID | AB_2882268 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | O00194 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
The Rab27 GTPase subfamily consists of two closely related homologs, Rab27a and Rab27b. Northern blot analysis revealed that Rab27b is expressed significantly only in testis, in which the predominant transcript was 1.4 kb in size. An 8-kb mRNA of unknown origin was detected in many tissues. Rab27b is associated with tubulovesicle membranes in the parietal cell and Rab27b may play a role in stimulation-associated membrane recruitment and gastric acid secretion. Rab27b is recently reported as a marker for breast cancer progression. It regulates invasive growth and metastasis in ER-positive breast cancer cell lines, and increased expression is associated with poor prognosis in humans.