验证数据展示
产品信息
66650-1-PBS targets RASGRP3 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with Human, mouse samples.
| 经测试应用 | WB, IF/ICC, Indirect ELISA Application Description |
| 经测试反应性 | Human, mouse |
| 免疫原 | RASGRP3 fusion protein Ag3810 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG2a |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | RAS guanyl releasing protein 3 (calcium and DAG-regulated) |
| 别名 | GRP3, KIAA0846, Ras guanyl releasing protein 3, RAS-GRP, RASGRP3 |
| 计算分子量 | 690 aa, 78 kDa |
| 观测分子量 | 78 kDa |
| GenBank蛋白编号 | BC027849 |
| 基因名称 | RASGRP3 |
| Gene ID (NCBI) | 25780 |
| RRID | AB_2882007 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | Q8IV61 |
| 储存缓冲液 | PBS only , pH 7.3 |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
AS guanyl releasing protein 3 (RasGRP3) is a member of the RasGRP family and is able to promote guanine nucleotide exchange of Ha-Ras, R-Ras and Rap1 (PMID: 9582122). RasGRP3 is involved in a diverse range of important biological processes. RasGRP3 has emerged as an important mediator of signaling downstream from receptor coupled phosphoinositide turnover in B and T cells. Overexpression of RasGRP3 is commonly associated with many malignancies, such as pre-Bcell leukemia, Burkitt’s lymphoma and natural killer-like T-cell leukemia. Recently, it has been reported that upregulation of RASGRP3 expression in prostate cancer correlates with aggressive capabilities and predicts biochemical recurrence after radical prostatectomy (PMID: 24418912).
