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验证数据展示

  • IHC staining of mouse eye using 14855-1-AP (same clone as 14855-1-PBS)

    IHC staining of mouse eye using 14855-1-AP (same clone as 14855-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse eye tissue slide using 14855-1-AP (RD3 antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 14855-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with RD3 antibody included
  • WB analysis using 14855-1-AP (same clone as 14855-1-PBS)

    WB analysis using 14855-1-AP (same clone as 14855-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 14855-1-AP (RD3 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14855-1-PBS in a different storage buffer formulation.

  • IHC staining of rat eye using 14855-1-AP (same clone as 14855-1-PBS)

    IHC staining of rat eye using 14855-1-AP (same clone as 14855-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat eye tissue slide using 14855-1-AP (RD3 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 14855-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with RD3 antibody included
  • IHC staining of rat eye using 14855-1-AP (same clone as 14855-1-PBS)

    IHC staining of rat eye using 14855-1-AP (same clone as 14855-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat eye tissue slide using 14855-1-AP (RD3 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 14855-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with RD3 antibody included

RD3 Polyclonal antibody, PBS Only

RD3 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 14855-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

Retinal degeneration protein 3, retinal degeneration 3, Protein RD3, LCA12, C1orf36

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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Planning an IHC experiment? We recommend our IHCeasy RD3 Ready-To-Use IHC Kit. RD3 primary antibody included.

产品信息

14855-1-PBS targets RD3 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原 RD3 fusion protein Ag6641 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 retinal degeneration 3
别名 Retinal degeneration protein 3, retinal degeneration 3, Protein RD3, LCA12, C1orf36
计算分子量22.7 kDa
观测分子量 23 kDa
GenBank蛋白编号BC065541
基因名称 RD3
Gene ID (NCBI) 343035
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ7Z3Z2
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

RD3, or Retinal Degeneration 3, plays a critical role in regulating guanylate cyclase (GC) signaling and photoreceptor cell survival (PMID: 30559291). RD3 is highly conserved across vertebrates, with the human protein sharing high sequence identity with other primates and varying degrees of identity with other species (PMID: 29030614). The main functions of RD3 include inhibiting photoreceptor-specific guanylate cyclase activity and promoting the accumulation of retinal membrane guanylyl cyclase (RetGC) in the photoreceptor outer segment (PMID: 30559291). RD3 is essential for the normal expression of RetGC in photoreceptor cells and blocks RetGC catalytic activity. Mutations in the RD3 gene can lead to Leber congenital amaurosis type 12, which results in retinal degeneration. RD3 is also involved in the trafficking of RetGC from the endoplasmic reticulum to the photoreceptor outer segments, which is crucial for maintaining the normal function and survival of photoreceptors (PMID: 34537244).