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验证数据展示

  • WB analysis using 60128-1-Ig (same clone as 60128-1-PBS)

    WB analysis using 60128-1-Ig (same clone as 60128-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 60128-1-Ig (RENALASE antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60128-1-PBS in a different storage buffer formulation.

  • IHC staining of human kidney using 60128-1-Ig (same clone as 60128-1-PBS)

    IHC staining of human kidney using 60128-1-Ig (same clone as 60128-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney slide using 60128-1-Ig (RENALASE Antibody) at dilution of 1:50. This data was developed using the same antibody clone with 60128-1-PBS in a different storage buffer formulation.

  • IHC staining of human kidney using 60128-1-Ig (same clone as 60128-1-PBS)

    IHC staining of human kidney using 60128-1-Ig (same clone as 60128-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney slide using 60128-1-Ig (RENALASE Antibody) at dilution of 1:50. This data was developed using the same antibody clone with 60128-1-PBS in a different storage buffer formulation.

  • WB analysis using 60128-1-Ig (same clone as 60128-1-PBS)

    WB analysis using 60128-1-Ig (same clone as 60128-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 60128-1-Ig (RENALASE antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60128-1-PBS in a different storage buffer formulation.

RENALASE Monoclonal antibody, PBS Only

RENALASE Monoclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 60128-1-PBS

产品说明书

CloneNo. 3A12F5

宿主/亚型

Mouse / IgG1

种属反应性

human

应用

WB, IHC, Indirect ELISA

别名

C10orf59, 3A12F5, Monoamine oxidase C, MAO-C, MAO C

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

60128-1-PBS targets RENALASE in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原 RENALASE fusion protein Ag13061 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 chromosome 10 open reading frame 59
别名 C10orf59, 3A12F5, Monoamine oxidase C, MAO-C, MAO C
计算分子量 38 kDa
观测分子量 38 kDa
GenBank蛋白编号BC005364
基因名称 RENALASE
Gene ID (NCBI) 55328
RRIDAB_2034903
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein G purification
UNIPROT IDQ5VYX0
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

RNLS, also named as Renalase, C10orf59 and MAO-C, belongs to the renalase family. It is probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. RNLS degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. It lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. RNLS has physiologically relevant catecholamine-oxidizing activity. (PMID:15841207 ) This antibody is specific to RNLS.