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RNASEH2A Monoclonal antibody, PBS Only

RNASEH2A Monoclonal Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

human

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1A2E8

Cat no : 67976-1-PBS

Print datasheet

Synonyms

ribonuclease H2, subunit A, Ribonuclease H2 subunit A, JUNB, EC:3.1.26.4, Aicardi-Goutieres syndrome 4 protein

验证数据展示

  • WB analysis using 67976-1-Ig (same clone as 67976-1-PBS)

    WB analysis using 67976-1-Ig (same clone as 67976-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67976-1-Ig (RNASEH2A antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67976-1-PBS in a different storage buffer formulation.

  • IHC staining of human skin cancer using 67976-1-Ig (same clone as 67976-1-PBS)

    IHC staining of human skin cancer using 67976-1-Ig (same clone as 67976-1-PBS)

    Immunohistochemical analysis of paraffin-embedded skin cancer slide using 67976-1-Ig (RNASEH2A antibody) at dilution of 1:1000 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67976-1-PBS in a different storage buffer formulation.

产品信息

67976-1-PBS targets RNASEH2A in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications WB, IHC, Indirect ELISA Application Description
Tested Reactivity human
Immunogen RNASEH2A fusion protein Ag9256 种属同源性预测
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Full Name ribonuclease H2, subunit A
Synonyms ribonuclease H2, subunit A, Ribonuclease H2 subunit A, JUNB, EC:3.1.26.4, Aicardi-Goutieres syndrome 4 protein
Calculated Molecular Weight 299 aa, 33 kDa
GenBank Accession NumberBC011748
Gene Symbol RNASEH2A
Gene ID (NCBI) 10535
RRIDAB_2918725
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDO75792
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

RNASEH2A(Ribonuclease H2 subunit A) is also named as RNASEHI, RNHIA and belongs to the RNase HII family and Eukaryotic subfamily. It is involved in the removal of the initiator RNA primers of Okazaki fragments, an essential step during chromosomal DNA replication of the lagging strand(PMID:9482870). It is an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Defects in RNASEH2A are the cause of Aicardi-Goutieres syndrome type 4 (AGS4).