RNF8 Monoclonal antibody, PBS Only

RNF8 Monoclonal Antibody for WB, Indirect ELISA
Cat No. 68521-1-PBS
CloneNo. 3G3H5

Host / Isotype

Mouse / IgG1

Reactivity

Human, mouse, rat, rabbit, pig

Applications

WB, Indirect ELISA

FLJ12013, KIAA0646, ring finger protein 8, RNF8

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size: 

-/ -


产品信息

68521-1-PBS targets RNF8 in WB, Indirect ELISA applications and shows reactivity with Human, mouse, rat, rabbit, pig samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity Human, mouse, rat, rabbit, pig
Immunogen RNF8 fusion protein Ag5292 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name ring finger protein 8
Synonyms FLJ12013, KIAA0646, ring finger protein 8, RNF8
Calculated Molecular Weight 485 aa, 56 kDa
Observed Molecular Weight65-70 kDa
GenBank Accession NumberBC007517
Gene Symbol RNF8
Gene ID (NCBI) 9025
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDO76064
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

RNF8, also named as KIAA0646 or E3 ubiquitin-protein ligase RNF8, is a 485 amino acid protein, which contains one RING-type zinc finger and one FHA domain. RNF8 localizes in the nucleus and belongs to the RNF8 family. E2-E3 ubiquitin ligase complex is composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites.

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