验证数据展示
产品信息
67086-1-PBS targets RUNX1T1 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat, pig samples.
经测试应用 | WB, IHC, Indirect ELISA Application Description |
经测试反应性 | human, mouse, rat, pig |
免疫原 | RUNX1T1 fusion protein Ag7893 种属同源性预测 |
宿主/亚型 | Mouse / IgG1 |
抗体类别 | Monoclonal |
产品类型 | Antibody |
全称 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) |
别名 | Eight twenty one protein, Cyclin-D-related protein, CDR, CBFA2T1, AML1T1 |
计算分子量 | 68 kDa |
观测分子量 | 70-75 kDa |
GenBank蛋白编号 | BC005850 |
基因名称 | RUNX1T1 |
Gene ID (NCBI) | 862 |
RRID | AB_2882394 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein G purification |
UNIPROT ID | Q06455 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
RUNX1T1 is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. Various transcript of the fusion gene has been reported. RUNX1T1 exists some isoforms with MV 68, 67,64, 48 and 44 kDa. The calcualted molecular weight of RUNX1T1 is 67 kDa, but modified RUNX1T1is about 70-75 kDa.