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CoraLite® Plus 647-conjugated RYR2 Polyclonal antibody

RYR2 Polyclonal Antibody for IF-P

Host / Isotype

Rabbit / IgG

Reactivity

Human, mouse

Applications

IF-P

Conjugate

CoraLite® Plus 647 Fluorescent Dye

Cat no : CL647-27587

Print datasheet

Synonyms

ARVC2, ARVD2, ryanodine receptor 2 (cardiac), RYR2, VTSIP

验证数据展示

  • IF Staining of mouse heart using CL647-27587

    IF Staining of mouse heart using CL647-27587

    Immunofluorescent analysis of (4% PFA) fixed mouse heart tissue using CoraLite® Plus 647 RYR2 antibody (CL647-27587) at dilution of 1:200.

经过测试的应用

Positive IF-P detected inmouse heart tissue
For other applications, we recommend the unconjugated version of this antibody, 27587-1-AP

推荐稀释比

ApplicationDilution
Immunofluorescence (IF)-PIF-P : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

CL647-27587 targets RYR2 in IF-P applications and shows reactivity with Human, mouse samples.

Tested Applications IF-P Application Description
Tested Reactivity Human, mouse
Immunogen RYR2 fusion protein Ag26296 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name ryanodine receptor 2 (cardiac)
Synonyms ARVC2, ARVD2, ryanodine receptor 2 (cardiac), RYR2, VTSIP
Calculated Molecular Weight 565 kDa
GenBank Accession NumberNM_001035
Gene Symbol RYR2
Gene ID (NCBI) 6262
Conjugate CoraLite® Plus 647 Fluorescent Dye
Excitation/Emission Maxima Wavelengths654 nm / 674 nm
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
Storage ConditionsStore at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

RYR2 belongs to the ryanodine receptor family. RYR2 provides communication between transverse-tubules and sarcoplasmic reticulum. Contraction of cardiac muscle is triggered by release of calcium ions from SR following depolarization of T-tubules. Defects in RYR2 are the cause of familial arrhythmogenic right ventricular dysplasia type 2 (ARVD2) which known as arrhythmogenic right ventricular cardiomyopathy 2 (ARVC2). Defects in RYR2 are the cause of catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) which known as stress-induced polymorphic ventricular tachycardia (VTSIP).

实验方案

Product Specific Protocols
IF protocol for CL Plus 647 RYR2 antibody CL647-27587Download protocol
Standard Protocols
Click here to view our Standard Protocols