验证数据展示
产品信息
68273-1-PBS targets SCN5A in Indirect ELISA, IHC, WB applications and shows reactivity with rabbit, rat, mouse, human samples.
| 经测试应用 | Indirect ELISA, IHC, WB Application Description |
| 经测试反应性 | rabbit, rat, mouse, human |
| 免疫原 | SCN5A fusion protein Ag19275 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | sodium channel, voltage-gated, type V, alpha subunit |
| 别名 | Nav1.5, HH1, CMPD2, CMD1E, CDCD2 |
| 计算分子量 | 2016 aa, 227 kDa |
| 观测分子量 | 227 kDa |
| GenBank蛋白编号 | BC140813 |
| 基因名称 | SCN5A |
| Gene ID (NCBI) | 6331 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein G purification |
| UNIPROT ID | Q14524 |
| 储存缓冲液 | PBS only , pH 7.3 |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Voltage-gated sodium channels are responsible for initiation and propagation of action potentials in the membranes of neurons and most electrically excitable cells (PMID: 10798388). These channels are composed of a large alpha subunit that forms the ion conduction pore and auxiliary beta subunits (PMID: 11486343). The alpha subunits form a gene family with at least 10 members. Nav1.5, encoded by the SCN5A gene in humans, is a pore forming alpha subunit of voltage-gated sodium channels. Nav1.5 is the principal Na+ channel isoform expressed in cardiomyocytes. Mutations in SCN5A gene have been linked to many cardiac electrical disorders, including the congenital and acquired long QT syndrome, Brugada syndrome, conduction slowing, sick sinus syndrome, atrial fibrillation, and dilated cardiomyopathy (PMID: 23123192).