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SDMA

SDMA (Symmetric dimethylarginine) 是一氧化氮 (NO) 合酶的内源性抑制剂。

CAS号

30344-00-4

分子式

C8H18N4O2

主要靶点

Endogenous Metabolite

仅限科研使用

Cat No : CM01908

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Synonyms

对称N,N-二甲基精氨酸|Symmetric dimethylarginine|NG,NG'-Dimethyl-L-arginine

验证数据展示

  • CAS No.: 30344-00-4

    SDMA
    CAS#: 30344-00-4

产品信息

SDMA is the most potent endogenous inhibitor of nitric oxide synthase (NOS), with higher levels in patients with end-stage renal disease (ESRD).

CAS号 30344-00-4
分子式 C8H18N4O2
主要靶点 Endogenous Metabolite
主要通路 代谢
分子量 202.25
纯度 ， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 对称N,N-二甲基精氨酸|Symmetric dimethylarginine|NG,NG'-Dimethyl-L-arginine

体外活性

SDMA inhibited dose dependently the NO synthesis in intact endothelial cells, whereas it had no effect on protein expression of NOS. This effect was associated with an increase in reactive oxygen species. Co-incubation with L-arginine but not D-arginine reversed the effect of SDMA on NOS pathway. Suggest that SDMA reduced the endothelial NO synthesis, probably by limiting L-arginine supply to NOS. It is concluded that SDMA might be a useful parameter for detecting patients in very early stages of chronic kidney disease and for determining their risk for developing cardiovascular disease[1].

溶解度

DMSO:50 mg/mL (247.22 mM)

参考文献

1.Bode-Boger, S. M . Symmetrical Dimethylarginine: A New Combined Parameter for Renal Function and Extent of Coronary Artery Disease[J]. Journal of the American Society of Nephrology, 2006, 17(4):1128-1134.
2.Toxic Dimethylarginines: Asymmetric  Dimethylarginine (ADMA) and Symmetric  Dimethylarginine (SDMA).

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This equation is commonly abbreviated as: C1V1 = C2V2

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