验证数据展示
产品信息
68287-1-PBS targets SERCA3 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with Human, mouse, rat samples.
Tested Applications | WB, IF/ICC, Indirect ELISA Application Description |
Tested Reactivity | Human, mouse, rat |
Immunogen | SERCA3 fusion protein Ag4527 种属同源性预测 |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Full Name | ATPase, Ca++ transporting, ubiquitous |
Synonyms | ATP2A3, Calcium pump 3, SERCA3, SR Ca(2+) ATPase 3 |
Calculated Molecular Weight | 1043 aa, 114 kDa |
Observed Molecular Weight | 97-110 kDa |
GenBank Accession Number | BC035729 |
Gene Symbol | SERCA3 |
Gene ID (NCBI) | 489 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein G purification |
UNIPROT ID | Q93084 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
The SERCA, which pumps cytosolic Ca2+ into the ER, is an imperative maintainer of ER Ca2+ homeostasis. The mammalian SERCA family is comprised of three tissue-specific members, SERCA1-3. SERCA3 is present in endothelial and epithelial cells of various tissues. SERCA3 helps regulate intracellular Ca2+, which is critical for maintaining normal INS secretion and is closely linked to metabolism, neuronal plasticity, gene transcription, cell growth, differentiation, apoptosis, protein folding and carcinogenesis. Several isoforms of SERCA3 exist due to the alternative splicing.