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  • Featured Product
  • KD/KO Validated

SETD1A Monoclonal antibody, PBS Only

SETD1A Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human, mouse, rat

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1C2G12

Cat No : 67936-1-PBS

Print datasheet

Synonyms

hSET1A, KIAA0339, KMT2F, Lysine N methyltransferase 2F, SET domain containing 1A, Set1, Set1A, SETD1A

验证数据展示

  • WB analysis using 67936-1-Ig (same clone as 67936-1-PBS)

    WB analysis using 67936-1-Ig (same clone as 67936-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67936-1-Ig (SETD1A antibody) at dilution of 1:10000 and incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67936-1-PBS in a different storage buffer formulation.

  • WB analysis of HEK-293 using 67936-1-Ig (same clone as 67936-1-PBS)

    WB analysis of HEK-293 using 67936-1-Ig (same clone as 67936-1-PBS)

    WB result of SETD1A antibody (67936-1-Ig; 1:2000; incubated at room temperature for 1.5 hours) with sh-Control and sh-SETD1A transfected HEK-293 cells. This data was developed using the same antibody clone with 67936-1-PBS in a different storage buffer formulation.

  • WB analysis of mouse brain using 67936-1-Ig (same clone as 67936-1-PBS)

    WB analysis of mouse brain using 67936-1-Ig (same clone as 67936-1-PBS)

    Mouse brain tissue was subjected to SDS PAGE followed by western blot with 67936-1-Ig (SETD1A antibody) at a dilution of 1:3000 and incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67936-1-PBS in a different storage buffer formulation.

产品信息

67936-1-PBS targets SETD1A in WB, Indirect ELISA applications and shows reactivity with Human, mouse, rat samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity Human, mouse, rat
Immunogen SETD1A fusion protein Ag30424 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name SET domain containing 1A
Synonyms hSET1A, KIAA0339, KMT2F, Lysine N methyltransferase 2F, SET domain containing 1A, Set1, Set1A, SETD1A
Calculated Molecular Weight 186 kDa
Observed Molecular Weight270 kDa
GenBank Accession NumberNM_014712
Gene Symbol SETD1A
Gene ID (NCBI) 9739
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDO15047
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

SETD1A is a SET domain-containing methyltransferase involved in the epigenetic regulation of transcription(PMID:12670868). It is the main catalytic component of a multiprotein complex that methylates lysine 4 of histone H3, a histone mark associated with gene activation (PMID:29937342). Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (PMID:31197650). Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated (PubMed:12670868). SETD1A has a calculated molecular weight of 186 kDa, and a 258 kDa band was also reported (PMID: 31076518).