验证数据展示
产品信息
19177-1-PBS targets SFRP5 in IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
Tested Applications | IHC, Indirect ELISA Application Description |
Tested Reactivity | human, mouse, rat |
Immunogen | SFRP5 fusion protein Ag5715 种属同源性预测 |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Full Name | secreted frizzled-related protein 5 |
Synonyms | |
Calculated Molecular Weight | 36 kDa |
GenBank Accession Number | BC050435 |
Gene Symbol | SFRP5 |
Gene ID (NCBI) | 6425 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
UNIPROT ID | Q5T4F7 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Secreted frizzled-related protein 5 (SFRP5) is an anti-inflammatory adipokine whose expression is perturbed in models of obesity and type 2 diabetes. SFRP5 is secreted by adipocytes and that it controls the micro-environment of white adipose tissue under conditions of metabolic stress (PMID: 20558665). SFRP5 gene consists of 317 amino acid residues and 3 coding exons and maps to chromosome 10q24.1 in humans. SFRP5 was initially found to be highly expressed in retinal pigment epithelium cells and moderately expressed in the pancreas. SFRP5 is involved in the pathological process of obesity, insulin resistance, dyslipidemia, inflammation, and fibrosis and is associated with obesity, T2D, and ASCVD (PMID: 31199714, PMID: 32004418).