验证数据展示
产品信息
67841-1-PBS targets SH3BP5 in WB, Indirect ELISA applications and shows reactivity with Human, rabbit, mouse, rat, pig, chicken samples.
Tested Applications | WB, Indirect ELISA Application Description |
Tested Reactivity | Human, rabbit, mouse, rat, pig, chicken |
Immunogen | SH3BP5 fusion protein Ag30252 种属同源性预测 |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Full Name | SH3-domain binding protein 5 (BTK-associated) |
Synonyms | SAB, SH3 domain binding protein 5, SH3BP 5, SH3BP5 |
Calculated Molecular Weight | 47 kDa |
Observed Molecular Weight | 75 kDa |
GenBank Accession Number | BC010123 |
Gene Symbol | SH3BP5 |
Gene ID (NCBI) | 9467 |
RRID | AB_2918603 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | O60239 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
SH3BP5(SH3 domain-binding protein 5) is also named as SAB. It is previously isolated in a screen for proteins capable of binding to the Src homology 3 (SH3) domain of Bruton's tyrosine kinase (Btk) and could play a role in targeting JNK and Btk to mitochondria and/or mediating cross-talk between the JNK and Btk signalling pathways. It has 2 isoforms produced by alternative splicing with the molecular mass of 50 kDa and 32 kDa. There are two bands of 83 kDa and 70 kDa can be detected in A431 and the larger species may correspond to splice variants of SH3BP5 or SH3BP5 proteins that have undergone post-translational modification(PMID:12167088). In addition, we detect the band of 32 kDa as the isoform 2 of SH3BP5 and another band of 62 kDa besides the 47 kDa and 80 kDa.