验证数据展示
产品信息
84805-4-PBS targets SIRT7 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human, rat samples.
Tested Applications | WB, IHC, IP, Indirect ELISA Application Description |
Tested Reactivity | human, rat |
Immunogen | SIRT7 fusion protein Ag31794 种属同源性预测 |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Full Name | sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae) |
Synonyms | SIR2L7, SIR2 like protein 7, NAD-dependent protein deacylase sirtuin-7, EC:2.3.1.286, EC:2.3.1.- |
Calculated Molecular Weight | 45KD |
Observed Molecular Weight | 45 kDa |
GenBank Accession Number | NM_016538 |
Gene Symbol | SIRT7 |
Gene ID (NCBI) | 51547 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purfication |
UNIPROT ID | Q9NRC8 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
SIRT7 (NAD-dependent deacetylase sirtuin-7), also known as SIR2L7, is a member of the class IV sirtuin family and is localized to the nucleolus. Expressed throughout the body, SIRT7 associates with rDNA genes where it interacts with histones and acts as a positive regulator of RNA polymerase I (Pol I). SIRT7 is a probable NAD-dependent deacetylase whose expression is upregulated in thyroid carcinoma cells. Overexpression of SIRT7 increases Pol I-mediated transcription, thereby speeding cell growth and contributing to the development of cancer.