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验证数据展示

  • FC experiment of human PBMCs using 98093-1-RR (same clone as 98093-1-PBS)

    FC experiment of human PBMCs using 98093-1-RR (same clone as 98093-1-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human SLAMF7/CD319 Rabbit Recombinant Antibody (98093-1-RR, Clone:241321F11) or 0.25 ug Isotype Control, and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with APC Anti-Human CD3. Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 98093-1-PBS in a different storage buffer formulation.

  • FC experiment of human PBMCs using 98093-1-RR (same clone as 98093-1-PBS)

    FC experiment of human PBMCs using 98093-1-RR (same clone as 98093-1-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human SLAMF7/CD319 Rabbit Recombinant Antibody (98093-1-RR, Clone:241321F11) (red) or 0.25 ug Isotype Control (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 98093-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98093-1-RR

    Affinity and Kinetic Characterization of 98093-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98093-1-RR against Human SLAMF7/CD319 were performed. The affinity constant is 0.634 nM.

Anti-Human SLAMF7/CD319 Rabbit Recombinant Antibody, PBS Only

SLAMF7/CD319 Uni-rAbTM Recombinant Antibody for FC
Cat No. 98093-1-PBS

产品说明书

CloneNo. 241321F11

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

别名

SLAMF7, FOAP-12, CS1, CRACC, CD319

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

98093-1-PBS targets SLAMF7/CD319 in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原 Recombinant Protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 SLAM family member 7
别名 SLAMF7, FOAP-12, CS1, CRACC, CD319
计算分子量 335 aa, 37 kDa
GenBank蛋白编号BC027867
基因名称 SLAMF7
Gene ID (NCBI) 57823
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDQ9NQ25
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Signaling lymphocyte activation molecule (SLAM) family receptors is a group of type I transmembrane receptors belonging to the immunoglobulin superfamily (PMID: 37251372). The SLAM family contains nine members that contain an extracellular segment comprising two or four Ig-like domains (V-like variable and C2-like constant), a transmembrane region and a cytoplasmic tail (PMID: 29662641). They are involved in various physiological and pathological processes, including the regulation of immunological responses and the route of viral entry. SLAMF7, also known as CS1, CRACC or CD319, is expressed on NK cells, CD8+ T lymphocytes, B lymphocytes, and mature dendritic cells (PMID: 28861320). It exerts both activating and inhibitory effects depending on the expression status of SAP or EAT-2. SLAMF7 is overexpressed in multiple myeloma and makes it a target for immunotherapy (PMID: 28861320).