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Anti-Human SLAMF7/CD319 Rabbit Recombinant Antibody, PBS Only

SLAMF7/CD319 Uni-rAbTM Recombinant Antibody for FC

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Conjugate

Unconjugated

CloneNo.

241321F11

Cat no : 98093-1-PBS

Print datasheet

Synonyms

SLAMF7, FOAP-12, CS1, CRACC, CD319

验证数据展示

  • FC experiment of human PBMCs using 98093-1-RR (same clone as 98093-1-PBS)

    FC experiment of human PBMCs using 98093-1-RR (same clone as 98093-1-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human SLAMF7/CD319 Rabbit Recombinant Antibody (98093-1-RR, Clone:241321F11) or 0.25 ug Isotype Control, and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with APC Anti-Human CD3. Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 98093-1-PBS in a different storage buffer formulation.

  • FC experiment of human PBMCs using 98093-1-RR (same clone as 98093-1-PBS)

    FC experiment of human PBMCs using 98093-1-RR (same clone as 98093-1-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human SLAMF7/CD319 Rabbit Recombinant Antibody (98093-1-RR, Clone:241321F11) (red) or 0.25 ug Isotype Control (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 98093-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98093-1-RR

    Affinity and Kinetic Characterization of 98093-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98093-1-RR against Human SLAMF7/CD319 were performed. The affinity constant is 0.634 nM.

产品信息

98093-1-PBS targets SLAMF7/CD319 in FC applications and shows reactivity with human samples.

Tested Applications FC Application Description
Tested Reactivity human
Immunogen Recombinant Protein 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name SLAM family member 7
Synonyms SLAMF7, FOAP-12, CS1, CRACC, CD319
Calculated Molecular Weight 335 aa, 37 kDa
GenBank Accession NumberBC027867
Gene Symbol SLAMF7
Gene ID (NCBI) 57823
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDQ9NQ25
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Signaling lymphocyte activation molecule (SLAM) family receptors is a group of type I transmembrane receptors belonging to the immunoglobulin superfamily (PMID: 37251372). The SLAM family contains nine members that contain an extracellular segment comprising two or four Ig-like domains (V-like variable and C2-like constant), a transmembrane region and a cytoplasmic tail (PMID: 29662641). They are involved in various physiological and pathological processes, including the regulation of immunological responses and the route of viral entry. SLAMF7, also known as CS1, CRACC or CD319, is expressed on NK cells, CD8+ T lymphocytes, B lymphocytes, and mature dendritic cells (PMID: 28861320). It exerts both activating and inhibitory effects depending on the expression status of SAP or EAT-2. SLAMF7 is overexpressed in multiple myeloma and makes it a target for immunotherapy (PMID: 28861320).