验证数据展示
产品信息
20350-1-PBS targets SLC1A5/ASCT2 in WB, IHC, IF/ICC, IF-P, FC (Intra), Indirect ELISA applications and shows reactivity with human, mouse samples.
Tested Applications | WB, IHC, IF/ICC, IF-P, FC (Intra), Indirect ELISA Application Description |
Tested Reactivity | human, mouse |
Immunogen | SLC1A5/ASCT2 fusion protein Ag14182 种属同源性预测 |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Full Name | solute carrier family 1 (neutral amino acid transporter), member 5 |
Synonyms | |
Calculated Molecular Weight | 541 aa, 57 kDa |
Observed Molecular Weight | 55-70 kDa |
GenBank Accession Number | BC000062 |
Gene Symbol | SLC1A5/ASCT2 |
Gene ID (NCBI) | 6510 |
RRID | AB_2878679 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
UNIPROT ID | Q15758 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
SLC1A5 (Solute Carrier Family 1, member 5), also named as ASCT2, a major glutamine transporter belonging to the SLC1 family and localized in the plasma membrane of several body districts. Consistent with the functions exerted by glutamine, SLC1A5 is involved in uptake of essential amino acids, activation of mTORC1 and glutamine-dependent tumor cell survival and growth. SLC1A5 is highly expressed in various malignancies and plays a critical role in the transformation, growth and survival of cancer cells (PMID: 30234109). High SLC1A5 expression is associated with poor prognosis in clear-cell renal cell carcinoma (PMID: 26599282).