验证数据展示
产品信息
84353-1-PBS targets SLCO2B1 in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human, mouse |
| 免疫原 | Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | solute carrier organic anion transporter family, member 2B1 |
| 别名 | OATPRP2, OATPB, OATP2B1, OATP B, KIAA0880 |
| 计算分子量 | 77 kDa |
| 观测分子量 | 61~74 kDa |
| GenBank蛋白编号 | NM_007256 |
| 基因名称 | SLCO2B1 |
| Gene ID (NCBI) | 11309 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purfication |
| UNIPROT ID | O94956 |
| 储存缓冲液 | PBS only , pH 7.3 |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Solute carrier organic anion (SLCO) gene families encode organic anion transport proteins (OATP), which are membrane transporters widely expressed in the human body that influx numerous compounds and drugs including androgens. SLCO2B1 is a member of an organic anion transporter family and has previously been shown to transport a multitude of drugs and steroid hormone conjugates (PMID: 35714613). High expression of SLCO2B1 is known to associate with the resistance to androgen deprivation therapy in prostate cancer (PMID: 29581838). OATP2B1 was insensitive to endoglycosidase H, an enzyme that cleaves only high mannose glycans, as expected for a mature protein undergoing complex glycosylation.