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SMRT / NCoR2 antibody (mAb) (Clone 5.10)

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

WB

CloneNo.

5.10

Cat No : 61105,61106 61105

Synonyms

SMRT, NCOr2, Nuclear receptor corepressor 2, CTG repeat protein 26, SMAP270, Silencing mediator of retinoic acid and thyroid hormone receptor, Thyroid and retinoic-acid-receptor-associated corepressor, TRAC, transcriptional corepressor for nuclear receptors, immune response, mediating DNA repair, neuronal differentiation, cardiac development, large corepressor complex, SIN3A/B, histone deacetylases, HDAC1 and HDAC2, TBL1, TBLR1, GPS2, clone 5.10, sample, monoclonal

验证数据展示

产品信息

Tested Applications WB

Tested Reactivity Human
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen This SMRT / NCoR2 antibody was raised against a recombinant protein corresponding to amino acids 2004-2310 of human SMRT / NCoR2.
Full Name SMRT / NCoR2 antibody (mAb) (Clone 5.10)
Synonyms SMRT, NCOr2, Nuclear receptor corepressor 2, CTG repeat protein 26, SMAP270, Silencing mediator of retinoic acid and thyroid hormone receptor, Thyroid and retinoic-acid-receptor-associated corepressor, TRAC, transcriptional corepressor for nuclear receptors, immune response, mediating DNA repair, neuronal differentiation, cardiac development, large corepressor complex, SIN3A/B, histone deacetylases, HDAC1 and HDAC2, TBL1, TBLR1, GPS2, clone 5.10, sample, monoclonal
Molecular weight 300 kDa
GenBank accession numberNP_006303
RRIDAB_2615017
Purification Method Protein G Chromatography
Buffer Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic.
Storage Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

背景介绍

SMRT / NCoR2 (Nuclear receptor corepressor 2, CTG repeat protein 26, SMAP270, Silencing mediator of retinoic acid and thyroid hormone receptor, Thyroid and retinoic-acid-receptor-associated corepressor, TRAC) is a transcriptional corepressor for nuclear receptors. SMRT / NCoR2 has been shown to play a role in regulating immune response, mediating DNA repair, and in neuronal differentiation and cardiac development. SMRT / NCoR2 is part of a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. It also includes TBL1, TBLR1, and GPS2 that help stabilize the overall structure of the complex. SMRT / NCoR2 mediates the transcriptional repression activity of nuclear receptors by promoting histone deacetylation and chromatin condensation, thus preventing access of the basal transcription machinery.