SMURF1 Monoclonal antibody, PBS Only
SMURF1 Monoclonal Antibody for WB, Indirect ELISA
Host / Isotype
Mouse / IgG1
Reactivity
Human, mouse
Applications
WB, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
2A7E4
验证数据展示
产品信息
68466-1-PBS targets SMURF1 in WB, Indirect ELISA applications and shows reactivity with Human, mouse samples.
| Tested Applications | WB, Indirect ELISA Application Description |
| Tested Reactivity | Human, mouse |
| Immunogen | SMURF1 fusion protein Ag30891 种属同源性预测 |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Full Name | SMAD specific E3 ubiquitin protein ligase 1 |
| Synonyms | hSMURF1, KIAA1625, SMURF1 |
| Calculated Molecular Weight | 86 kDa |
| Observed Molecular Weight | 86 kDa |
| GenBank Accession Number | NM_020429 |
| Gene Symbol | SMURF1 |
| Gene ID (NCBI) | 57154 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | Q9HCE7 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
SMURF1, also named as KIAA1625, is E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. SMURF1 interacts with receptor-regulated SMADs specific for the BMP pathway, SMAD1 and SMAD5, in order to trigger their ubiquitination and degradation and hence their inactivation. SMURF1 can be detected as 90-100 kDa when ubiquitinated (PMID:17576816, PMID:20484049).