验证数据展示
产品信息
68386-1-PBS targets SNX27 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Applications | WB, IF/ICC, Indirect ELISA Application Description |
| Tested Reactivity | human, mouse, rat |
| Immunogen | SNX27 fusion protein Ag9447 种属同源性预测 |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Full Name | sorting nexin family member 27 |
| Synonyms | Sorting nexin-27, My014, KIAA0488, 2C4G5 |
| Calculated Molecular Weight | 61 kDa, 60 kDa, 52 kDa, 28 kDa |
| Observed Molecular Weight | 61 kDa |
| GenBank Accession Number | BC012184 |
| Gene Symbol | SNX27 |
| Gene ID (NCBI) | 81609 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein G purification |
| UNIPROT ID | Q96L92 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Sorting nexin 27 (SNX27), a PDZ domain-containing protein, belongs to the sorting nexin family of proteins. SNX27 promotes the recycling of internalized transmembrane proteins from endosomes to the plasma membrane by linking PDZ-dependent cargo recognition to retromer-mediated transport (PMID: 21602791; 23563491). It has been shown that SNX27 deficiency contributes to synaptic and cognitive deficits by modulating glutamate receptor recycling in Down's syndrome (PMID: 23524343). SNX27 has also been proposed to have a role in regulating β-amyloid (Aβ) generation by modulating γ-secretase activity, which is a molecular mechanism for Aβ-dependent pathogenesis in both Down's syndrome and Down's syndrome (PMID: 25437557).
