验证数据展示
产品信息
67361-1-PBS targets SPAST in WB, IHC, IF-P, Indirect ELISA applications and shows reactivity with Human, mouse samples.
| Tested Applications | WB, IHC, IF-P, Indirect ELISA Application Description |
| Tested Reactivity | Human, mouse |
| Immunogen | SPAST fusion protein Ag18866 种属同源性预测 |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Full Name | spastin |
| Synonyms | ADPSP, FSP2, KIAA1083, SPAST, Spastic paraplegia 4 protein, spastin, SPG4 |
| Calculated Molecular Weight | 616 aa, 67 kDa |
| Observed Molecular Weight | 55 kDa |
| GenBank Accession Number | BC150260 |
| Gene Symbol | SPAST |
| Gene ID (NCBI) | 6683 |
| RRID | AB_2882613 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | Q9UBP0 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
SPAST encodes a microtubule-severing protein called spastin. By severing microtubules into small segments, SPAST participates in the regeneration of neurites. Mutations in the SPAST gene (previously known as SPG4) are the most common causes of hereditary spastic paraplegia (HSP-SPG4). Mammalian cells express at least two spastin isoforms, a less-abundant full-length form (M1-spastin, 68 kDa) and a more highly expressed isoform (M87-spastin, 60 kDa) that lacks the N-terminal 86 amino acids of the full-length protein. Also, there are two additional 64 kDa and 55 kDa isoforms due to alternative splicing of SPG4 exon 4. This antibody recognizes all these isoforms of spastin.