验证数据展示
产品信息
60112-1-PBS targets IL-1RL1/ST2 in WB, ELISA applications and shows reactivity with human, mouse, rat, pig samples.
| Tested Applications | WB, ELISA Application Description |
| Tested Reactivity | human, mouse, rat, pig |
| Immunogen | IL-1RL1/ST2 fusion protein Ag2555 种属同源性预测 |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Full Name | interleukin 1 receptor-like 1 |
| Synonyms | IL1RL1, IL-1RL1, FIT 1, EC:3.2.2.6, DER4 |
| Calculated Molecular Weight | 63 kDa, 37 kDa, 30 kDa |
| Observed Molecular Weight | 63 kDa |
| GenBank Accession Number | BC030975 |
| Gene Symbol | IL1RL1 |
| Gene ID (NCBI) | 9173 |
| RRID | AB_2264785 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | Q01638 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
ST2, also known as IL1RL1, is a member of the IL-1 superfamily and serves as the receptor for IL-33. It plays a major role in immune and inflammatory responses. ST2 is expressed by various types of immune cells including Th2 cells, mast cells, type 2 innate lymphoid cells, eosinophils, basophils, NK cells, and non-immune cells, including cardiomyocytes. Two forms of ST2 exist: a membrane-bound form and a soluble form (sST2). The membrane-bound form activates the MyD88/NF-κB signaling pathway to enhance mast cell, Th2, regulatory T cell (Treg), and innate lymphoid cell type 2 functions. sST2 acts as a decoy receptor. (PMID: 27055914; 23999434; 28484466)
