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STIM1 Monoclonal antibody, PBS Only

STIM1 Monoclonal Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

rat, human, mouse

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1D3A3

Cat no : 66189-1-PBS

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Synonyms

STIM1



产品信息

66189-1-PBS targets STIM1 in WB, IHC, Indirect ELISA applications and shows reactivity with rat, human, mouse samples.

Tested Applications WB, IHC, Indirect ELISA Application Description
Tested Reactivity rat, human, mouse
Immunogen STIM1 fusion protein Ag17914 种属同源性预测
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Full Name stromal interaction molecule 1
Synonyms STIM1
Calculated Molecular Weight 685 aa, 77 kDa
Observed Molecular Weight 77 kDa
GenBank Accession NumberBC021300
Gene Symbol STIM1
Gene ID (NCBI) 6786
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ13586
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

STIM1, also named as GOK, is an ER Ca2+ sensor. Upon Ca2+ store depletion, STIM1 clusters at ER-plasma membrane junctions where it interacts with and gates Ca2+-permeable Orai1 ion channels. STIM1 is implicated in tumor growth suppression and stromal-haematopoietic cell interactions. Defacts in STIM1 gene can cause immune dysfunction with impaired T-cell activation. STIM1 can inhibit L-type voltage-gated Ca(2+) channels in neurons. Temperature is an important regulator of STIM1 function.The MW of STIM1 is about 80-90 kDa which may be due to the phosphorylation or glycosylation forms.