CoraLite® Plus 488-conjugated STK11/LKB1 Monoclonal antibody
STK11/LKB1 Monoclonal Antibody for
Host / Isotype
Mouse / IgG1
Reactivity
Human, mouse, rat
Applications
Conjugate
CoraLite® Plus 488 Fluorescent Dye
CloneNo.
2D11E5
验证数据展示
Planning an IHC experiment? We recommend our IHCeasy STK11 Ready-To-Use IHC Kit. STK11 primary antibody included.
For other applications, we recommend the unconjugated version of this antibody, 68016-1-Ig
产品信息
CL488-68016 targets STK11/LKB1 in applications and shows reactivity with Human, mouse, rat samples.
| Tested Applications | Application Description |
| Tested Reactivity | Human, mouse, rat |
| Immunogen | Peptide 种属同源性预测 |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Full Name | serine/threonine kinase 11 |
| Synonyms | LKB1, STK11, STK11/ LKB1, PJS, Liver kinase B1 |
| Calculated Molecular Weight | 49 kDa |
| Observed Molecular Weight | 50-55 kDa |
| GenBank Accession Number | BC007981 |
| Gene Symbol | LKB1 |
| Gene ID (NCBI) | 6794 |
| Conjugate | CoraLite® Plus 488 Fluorescent Dye |
| Excitation/Emission Maxima Wavelengths | 493 nm / 522 nm |
| Form | Liquid |
| Purification Method | Protein G purification |
| UNIPROT ID | Q15831 |
| Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| Storage Conditions | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
STK11(serine/threonine-protein kinase 11) is also named as LKB1, PJS, and belongs to the protein kinase superfamily. It controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. The tumour suppressor protein LKB1 is a serine/threonine kinase that has been causally linked to Peutz-Jeghers syndrome (PJS). Defects in STK11 are a cause of Peutz-Jeghers syndrome (PJS) and defects in STK11 have been associated with testicular germ cell tumor (TGCT) and some sporadic cancers, especially lung cancers. STK11 has 2 isoforms with MW of 49 kDa and 45 kDa, and can be detected as 50-54 kDa after posttranslational modification.
