CoraLite®594-conjugated STK11/LKB1 Monoclonal antibody
STK11/LKB1 Monoclonal Antibody for WB
Host / Isotype
Mouse / IgG1
Reactivity
Human, Mouse, Rat
Applications
WB
Conjugate
CoraLite®594 Fluorescent Dye
CloneNo.
1H8E4
验证数据展示
经过测试的应用
| Positive WB detected in | HeLa cells, HEK-293 cells, Jurkat cells |
Planning an IHC experiment? We recommend our IHCeasy STK11 Ready-To-Use IHC Kit. STK11 primary antibody included.
推荐稀释比
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:500-1:1000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
CL594-66719 targets STK11/LKB1 in WB applications and shows reactivity with Human, Mouse, Rat samples.
| Tested Applications | WB Application Description |
| Tested Reactivity | Human, Mouse, Rat |
| Immunogen | STK11/LKB1 fusion protein Ag13436 种属同源性预测 |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Full Name | serine/threonine kinase 11 |
| Synonyms | LKB1, PJS, serine/threonine kinase 11, STK11, STK11/LKB1 |
| Calculated Molecular Weight | 49 kDa |
| Observed Molecular Weight | 45-49 kDa |
| GenBank Accession Number | BC007981 |
| Gene Symbol | LKB1 |
| Gene ID (NCBI) | 6794 |
| RRID | AB_2920027 |
| Conjugate | CoraLite®594 Fluorescent Dye |
| Excitation/Emission Maxima Wavelengths | 588 nm / 604 nm |
| Form | Liquid |
| Purification Method | Protein G purification |
| UNIPROT ID | Q15831 |
| Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| Storage Conditions | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
STK11(serine/threonine-protein kinase 11) is also named as LKB1, PJS, and belongs to the protein kinase superfamily. It controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. The tumour suppressor protein LKB1 is a serine/threonine kinase that has been causally linked to Peutz-Jeghers syndrome (PJS). Defects in STK11 are a cause of Peutz-Jeghers syndrome (PJS) and defects in STK11 have been associated with testicular germ cell tumor (TGCT) and some sporadic cancers, especially lung cancers. STK11 has 2 isoforms with MW of 49 kDa and 45 kDa, and can be detected as 50-54 kDa after posttranslational modification.
实验方案
| Product Specific Protocols | |
|---|---|
| WB protocol for CL594 STK11/LKB1 antibody CL594-66719 | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |