验证数据展示
产品信息
83081-2-PBS targets STK39 as part of a matched antibody pair:
MP00106-2: 83081-2-PBS capture and 83081-4-PBS detection (validated in Cytometric bead array)
MP00106-3: 83081-2-PBS capture and 83081-1-PBS detection (validated in Sandwich ELISA)
Unconjugated rabbit recombinant monoclonal antibody in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation. Created using Proteintech’s proprietary in-house recombinant technology. Recombinant production enables unrivalled batch-to-batch consistency, easy scale-up, and future security of supply.
This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.
经测试应用 | WB, IF/ICC, IF-P, Cytometric bead array, Sandwich ELISA, Indirect ELISA, Sample test Application Description |
经测试反应性 | human, mouse, rat |
免疫原 | STK39 fusion protein Ag34503 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Recombinant |
产品类型 | Antibody |
全称 | serine threonine kinase 39 (STE20/SPS1 homolog, yeast) |
别名 | Ste 20 related kinase, SPAK, PASK, DCHT, 230382G9 |
计算分子量 | 59 kDa |
观测分子量 | 62 kDa |
GenBank蛋白编号 | BC166614 |
基因名称 | STK39 |
Gene ID (NCBI) | 27347 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purification |
UNIPROT ID | Q9UEW8 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
STK39 (Serine/Threonine Kinase 39) is a proline- and alanine-rich Ste20-related kinase (also named as SPAK), which is composed of a short N-terminal proline and alanine repeats (PAPA box), a kinase catalytic domain and a C-terminal regulatory domain (PMID: 16382158). In mammalians, STK39 plays an important role in ion homeostasis by regulating the cation chloride cotransporters' activities, which is crucial for the modulation of renal salt transport and blood pressure (PMID: 33500714). Notably, STK39 is also implicated in the regulation of tumor cell proliferation, migration, and invasion in multiple cancers, including osteosarcoma and cervical cancer (PMID: 34335956).