验证数据展示
产品信息
84017-5-PBS targets SUMO2/3 in IF/ICC, Indirect ELISA applications and shows reactivity with human samples.
| Tested Applications | IF/ICC, Indirect ELISA Application Description |
| Tested Reactivity | human |
| Immunogen | SUMO2/3 fusion protein Ag1135 种属同源性预测 |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Full Name | SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae) |
| Synonyms | SUMO3, SUMO 2, SMT3H1, SMT3A, SMT3 homolog 1 |
| Calculated Molecular Weight | 12 kDa |
| GenBank Accession Number | BC008420 |
| Gene Symbol | SUMO3 |
| Gene ID (NCBI) | 6612 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purfication |
| UNIPROT ID | P55854 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Ubiquitin is most famous for its function in targeting proteins for degradation by the 26S proteasome, ubiquitin needs to be attached to a substrate in chains (polyubiquitylation) before being recognized by proteasome. Similarly, SUMO (small ubiquitin-related modifier) can be linked to substrates in chains (polysumoylation), SUMO modification has been implicated in many important cellular processes including the control of genome stability, signal transduction, targeting to and formation of nuclear compartments, cell cycle and meiosis. There are 4 confirmed SUMO isoforms in human, SUMO-1, SUMO-2, SUMO-3 and SUMO-4. SUMO-2 and SUMO-3 are nearly identical but are distinct from SUMO-1. SUMO2/3 conjugation was recently widely involved in neuroprotective activities. A substitution (M55V) of SUMO4 was strongly associated with the pathogenesis of type 1 diabetes (T1D) involving NF kappa B related mechanisms.
