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验证数据展示

  • WB analysis using 18040-1-AP (same clone as 18040-1-PBS)

    WB analysis using 18040-1-AP (same clone as 18040-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 18040-1-AP (Securin antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18040-1-PBS in a different storage buffer formulation.

  • IHC staining of human urothelial carcinoma using 18040-1-AP (same clone as 18040-1-PBS)

    IHC staining of human urothelial carcinoma using 18040-1-AP (same clone as 18040-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human urothelial carcinoma tissue slide using 18040-1-AP (Securin antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18040-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with PTTG1/Securin antibody included
  • IF Staining of HepG2 using 18040-1-AP (same clone as 18040-1-PBS)

    IF Staining of HepG2 using 18040-1-AP (same clone as 18040-1-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed HepG2 cells using Securin / PTTG1 antibody (18040-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 18040-1-PBS in a different storage buffer formulation.

  • IF Staining of U2OS using 18040-1-AP (same clone as 18040-1-PBS)

    IF Staining of U2OS using 18040-1-AP (same clone as 18040-1-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed U2OS cells using Securin antibody (18040-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 18040-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

Securin Polyclonal antibody, PBS Only

Securin Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 18040-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, IF/ICC, Indirect ELISA

别名

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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Planning an IHC experiment? We recommend our IHCeasy PTTG1/Securin Ready-To-Use IHC Kit. PTTG1/Securin primary antibody included.

产品信息

18040-1-PBS targets Securin in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原 Securin fusion protein Ag12670 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 pituitary tumor-transforming 1
别名
计算分子量 202 aa, 22 kDa
观测分子量28 kDa
GenBank蛋白编号BC101834
基因名称 Securin
Gene ID (NCBI) 9232
RRIDAB_2173410
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDO95997
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Securin, also known as the pituitary tumor transforming gene (PTTG1), was first isolated from rat pituitary tumor cells. Securin is a multi-functional protein that regulates sister chromatin segregation in mitosis, DNA repair, gene transcription, metabolism, and organ development. Securin is normally expressed in tissues with high proliferative activity, including the spleen, thymus gland, and testis, whereas it is rarely expressed in differentiated mature tissues (PMID: 22563433, PMID: 36123907). The calculated molecular weight of Securin is 22 kDa. With post-translational modification, the molecular weight of Securin will be migrated to 28 kDa.