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Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

验证数据展示

  • FC experiment of human peripheral blood leukocytes using 98177-1-RR (same clone as 98177-1-PBS)

    FC experiment of human peripheral blood leukocytes using 98177-1-RR (same clone as 98177-1-PBS)

    1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human Siglec-8 Rabbit Recombinant Antibody (98177-1-RR, Clone: 241275A5) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9), and PE-conjugated Goat Anti-Rabbit IgG. Cells were co-stained with CoraLite® Plus 647 Anti-Human CD16. Cells were not fixed. This data was developed using the same antibody clone with 98177-1-PBS in a different storage buffer formulation.

  • FC experiment of human peripheral blood leukocytes using 98177-1-RR (same clone as 98177-1-PBS)

    FC experiment of human peripheral blood leukocytes using 98177-1-RR (same clone as 98177-1-PBS)

    1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human Siglec-8 Rabbit Recombinant Antibody (98177-1-RR, Clone: 241275A5) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-conjugated Goat Anti-Rabbit IgG. Cells were not fixed. This data was developed using the same antibody clone with 98177-1-PBS in a different storage buffer formulation.

Anti-Human Siglec-8 Rabbit Recombinant Antibody, PBS Only

Siglec-8 Uni-rAbTM Recombinant Antibody for FC
Cat No. 98177-1-PBS

产品说明书

CloneNo. 241275A5

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

别名

SIGLEC8, SIGLEC 8, Sialoadhesin family member 2, Sialic acid-binding Ig-like lectin 8, SAF2

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

98177-1-PBS targets Siglec-8 in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原 Recombinant Protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 sialic acid binding Ig-like lectin 8
别名 SIGLEC8, SIGLEC 8, Sialoadhesin family member 2, Sialic acid-binding Ig-like lectin 8, SAF2
计算分子量 499 aa, 54 kDa
GenBank蛋白编号BC053319
基因名称 SIGLEC8
Gene ID (NCBI) 27181
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDQ9NYZ4
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Sialic acid-binding Ig-like lectin 8 (Siglec-8), also known as SAF2, is a sialic acid-binding immunoglobulin-like lectin that belongs to the SIGLEC family of the Ig superfamily (PMID: 10856141). Siglec-8 is a single-pass transmembrane protein containing three extracellular immunoglobulin-like domains, a transmembrane region, and a cytoplasmic tail (PMID: 10625619). It is an inhibitory receptor selectively expressed on human mast cells and eosinophils, and at low levels on basophils (PMID: 10856141; 33374255). Engagement of Siglec-8 with antibody results in inhibiting IgE-mediated mast cell responses and reducing allergic inflammation (PMID: 32814824).