- Featured Product
- KD/KO Validated
TBK1 Monoclonal antibody
TBK1 Monoclonal Antibody for WB, ELISA
Host / Isotype
Mouse / IgG2b
Reactivity
Human, Mouse, Rat and More (3)
Applications
WB, ELISA and More (2)
Conjugate
Unconjugated
CloneNo.
2D7B1
验证数据展示
经过测试的应用
| Positive WB detected in | HEK-293 cells, A549 cells, U2OS cells, HepG2 cells, Jurkat cels, HSC-T6 cells, NIH/3T3 cells, 4T1 cells, HeLa cells, K-562 cells, LNCaP cells, Jurkat cells |
推荐稀释比
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:500-1:2000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
67211-1-Ig targets TBK1 in WB, IP, IF, ELISA applications and shows reactivity with Human, Mouse, Rat samples.
| Tested Applications | WB, ELISA Application Description |
| Cited Applications | WB, IP, IF |
| Tested Reactivity | Human, Mouse, Rat |
| Cited Reactivity | human, mouse, rat |
| Immunogen | TBK1 fusion protein Ag28894 种属同源性预测 |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Full Name | TANK-binding kinase 1 |
| Synonyms | FLJ11330, NAK, NF kappa B activating kinase, T2K, TANK binding kinase 1, TBK1 |
| Observed Molecular Weight | 84 kDa |
| GenBank Accession Number | BC034950 |
| Gene Symbol | TBK1 |
| Gene ID (NCBI) | 29110 |
| RRID | AB_2882504 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | Q9UHD2 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
TBK1, also named as tumor necrosis factor (TNF) receptor-associated factor NF-kB activator (TANK)-binding kinase 1 (TBK1), NF-kB-activating kinase (NAK), T2K, is a multimeric kinase that modulates inflammation and autophagy. It is a ubiquitously expressed serine-threonine kinase belonging to the 'noncanonical IkB kinases' (IKKs) recognized for its critical role in regulating type I IFN production (PMID: 27211305). And TBK1 is an important player in yet another critical cellular function, autophagy. This antibody is specific for TBK1.
实验方案
| Product Specific Protocols | |
|---|---|
| WB protocol for TBK1 antibody 67211-1-Ig | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
发表文章
| Species | Application | Title |
|---|---|---|
J Med Chem Development of Orally Bioavailable Amidobenzimidazole Analogues Targeting Stimulator of Interferon Gene (STING) Receptor | ||
J Virol Porcine deltacoronavirus nsp5 antagonizes type I interferon signaling by cleaving IFIT3 | ||
Front Immunol Swine Acute Diarrhea Syndrome Coronavirus Nucleocapsid Protein Antagonizes Interferon-β Production via Blocking the Interaction Between TRAF3 and TBK1. | ||
Heliyon Metformin promotes cGAS/STING signaling pathway activation by blocking AKT phosphorylation in gastric cancer | ||
Biomed Pharmacother IFI16 promotes cervical cancer progression by upregulating PD-L1 in immunomicroenvironment through STING-TBK1-NF-kB pathway. | ||
Cell Mol Neurobiol Neutrophil Extracellular Traps Regulate Surgical Brain Injury by Activating the cGAS-STING Pathway |