TDO2 Recombinant antibody

TDO2 Recombinant Antibody for WB, ELISA
Cat No. 83236-2-RR

产品说明书

CloneNo. 240068C2

宿主/亚型

Rabbit / IgG

种属反应性

human, rat

应用

WB, ELISA

TRPO, TPH2, TO, TDO, EC:1.13.11.11

缓冲液配方:  PBS and Azide
PBS and Azide
PBS Only
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -


经过测试的应用

Positive WB detected inrat liver tissue

推荐稀释比

应用推荐稀释比
Western Blot (WB)WB : 1:5000-1:50000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

83236-2-RR targets TDO2 in WB, ELISA applications and shows reactivity with human, rat samples.

经测试应用 WB, ELISA Application Description
经测试反应性 human, rat
免疫原 TDO2 fusion protein Ag8531 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 tryptophan 2,3-dioxygenase
别名 TRPO, TPH2, TO, TDO, EC:1.13.11.11
计算分子量 406 aa, 48 kDa
观测分子量 40-50 kDa
GenBank蛋白编号BC005355
基因名称 TDO2
Gene ID (NCBI) 6999
RRIDAB_3670913
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP48775
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

TDO2 (tryptophan 2,3-dioxygenase), IDO1 (indoleamine 2,3-dioxygenase 1) and IDO2 are three enzymes that catalyze the amino acid tryptophan into kynurenine in the kynurenine pathway (PMID: 23090118, 28469468). TDO2 plays an important role in neurological diseases such as Alzheimer's disease, Parkinson's disease and autism. Overexpression of TDO2 promoted tumor cell survival and was correlated with tumor grade and poor prognosis in triple negative breast cancer, brain tumors and esophageal squamous cell carcinoma. TDO2 may be a potential therapeutic target in some cancers. (PMID: 21976023, 30134247)

实验方案

Product Specific Protocols
WB protocol for TDO2 antibody 83236-2-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols
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