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验证数据展示

  • WB analysis of rat liver using 83236-2-RR (same clone as 83236-2-PBS)

    WB analysis of rat liver using 83236-2-RR (same clone as 83236-2-PBS)

    rat liver tissue were subjected to SDS PAGE followed by western blot with 83236-2-RR (TDO2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83236-2-PBS in a different storage buffer formulation.

  • Cytometric bead array standard curve of MP00219-1

    Cytometric bead array standard curve of MP00219-1

    Cytometric bead array standard curve of MP00219-1, TDO2 Recombinant Matched Antibody Pair, PBS Only. Capture antibody: 83236-2-PBS. Detection antibody: 83236-1-PBS. Standard: Ag8531. Range: 1.25-40 ng/mL.

  • Cytometric bead array standard curve of MP00219-2

    Cytometric bead array standard curve of MP00219-2

    Cytometric bead array standard curve of MP00219-2, TDO2 Recombinant Matched Antibody Pair, PBS Only. Capture antibody: 83236-2-PBS. Detection antibody: 83236-3-PBS. Standard: Ag8531. Range: 1.25-40 ng/mL.

  • Affinity and Kinetic Characterization of 83236-2-RR

    Affinity and Kinetic Characterization of 83236-2-RR

    Biolayer interferometry (BLl) kinetic assays of 83236-2-RR against Human TDO2 were performed. The affinity constant is below 1 pM.

TDO2 Recombinant antibody, PBS Only (Capture)

TDO2 Uni-rAbTM Recombinant Antibody for WB, Cytometric bead array, Indirect ELISA
Cat No. 83236-2-PBS

产品说明书

CloneNo. 240068C2

宿主/亚型

Rabbit / IgG

种属反应性

human, rat

应用

WB, Cytometric bead array, Indirect ELISA

别名

TRPO, TPH2, TO, TDO, EC:1.13.11.11

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

83236-2-PBS targets TDO2 as part of a matched antibody pair:

MP00219-1: 83236-2-PBS capture and 83236-1-PBS detection (validated in Cytometric bead array)

MP00219-2: 83236-2-PBS capture and 83236-3-PBS detection (validated in Cytometric bead array)

Unconjugated rabbit recombinant monoclonal antibody in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation. Created using Proteintech’s proprietary in-house recombinant technology. Recombinant production enables unrivalled batch-to-batch consistency, easy scale-up, and future security of supply.

This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.

经测试应用 WB, Cytometric bead array, Indirect ELISA Application Description
经测试反应性 human, rat
免疫原 TDO2 fusion protein Ag8531 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 tryptophan 2,3-dioxygenase
别名 TRPO, TPH2, TO, TDO, EC:1.13.11.11
计算分子量 406 aa, 48 kDa
观测分子量 40-50 kDa
GenBank蛋白编号BC005355
基因名称 TDO2
Gene ID (NCBI) 6999
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP48775
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TDO2 (tryptophan 2,3-dioxygenase), IDO1 (indoleamine 2,3-dioxygenase 1) and IDO2 are three enzymes that catalyze the amino acid tryptophan into kynurenine in the kynurenine pathway (PMID: 23090118, 28469468). TDO2 plays an important role in neurological diseases such as Alzheimer's disease, Parkinson's disease and autism. Overexpression of TDO2 promoted tumor cell survival and was correlated with tumor grade and poor prognosis in triple negative breast cancer, brain tumors and esophageal squamous cell carcinoma. TDO2 may be a potential therapeutic target in some cancers. (PMID: 21976023, 30134247)