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Species Reactivity
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验证数据展示

  • WB analysis of MCF-7 using 66893-1-Ig (same clone as 66893-1-PBS)

    WB analysis of MCF-7 using 66893-1-Ig (same clone as 66893-1-PBS)

    MCF-7 cells were subjected to SDS PAGE followed by western blot with 66893-1-Ig (TERF2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66893-1-PBS in a different storage buffer formulation.

  • IHC staining of human gliomas using 66893-1-Ig (same clone as 66893-1-PBS)

    IHC staining of human gliomas using 66893-1-Ig (same clone as 66893-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human gliomas tissue slide using 66893-1-Ig (TERF2 antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66893-1-PBS in a different storage buffer formulation.

  • IHC staining of human gliomas using 66893-1-Ig (same clone as 66893-1-PBS)

    IHC staining of human gliomas using 66893-1-Ig (same clone as 66893-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human gliomas tissue slide using 66893-1-Ig (TERF2 antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66893-1-PBS in a different storage buffer formulation.

  • WB analysis of HEK-293 using 66893-1-Ig (same clone as 66893-1-PBS)

    WB analysis of HEK-293 using 66893-1-Ig (same clone as 66893-1-PBS)

    HEK-293 cells were subjected to SDS PAGE followed by western blot with 66893-1-Ig (TERF2 antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66893-1-PBS in a different storage buffer formulation.

  • WB analysis of Jurkat using 66893-1-Ig (same clone as 66893-1-PBS)

    WB analysis of Jurkat using 66893-1-Ig (same clone as 66893-1-PBS)

    Jurkat cells were subjected to SDS PAGE followed by western blot with 66893-1-Ig (TERF2 antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66893-1-PBS in a different storage buffer formulation.

  • WB analysis of 4T1 using 66893-1-Ig (same clone as 66893-1-PBS)

    WB analysis of 4T1 using 66893-1-Ig (same clone as 66893-1-PBS)

    4T1 cells were subjected to SDS PAGE followed by western blot with 66893-1-Ig (TERF2 antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66893-1-PBS in a different storage buffer formulation.

TERF2 Monoclonal antibody, PBS Only

TERF2 Monoclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 66893-1-PBS

产品说明书

CloneNo. 5B1E1

宿主/亚型

Mouse / IgG1

种属反应性

Human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

Telomeric DNA binding protein, TERF2, TRBF2, TRF2, TTAGGG repeat binding factor 2

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

66893-1-PBS targets TERF2 in WB, IHC, Indirect ELISA applications and shows reactivity with Human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 Human, mouse, rat
免疫原 TERF2 fusion protein Ag28513 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 telomeric repeat binding factor 2
别名 Telomeric DNA binding protein, TERF2, TRBF2, TRF2, TTAGGG repeat binding factor 2
计算分子量 56 kDa
观测分子量 60-65.32-35 kDa
GenBank蛋白编号BC024890
基因名称 TERF2
Gene ID (NCBI) 7014
RRIDAB_2882222
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDQ15554
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TERF2, also named as TRF2 and Telomeric repeat-binding factor 2, is a 542 amino acid protein, which contains 1 HTH myb-type DNA-binding domain and localizes in the Nucleus. TRF2 binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. TERF2 is a component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. TERF2 together with DCLRE1B/Apollo, is required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B), which is needed for telomere replication during fork passage and prevent aberrant telomere topology. TERF2 recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length. TERF2 exists some isoforms with MV 60 kDa and 32 kDa.