CoraLite® Plus 488-conjugated TGF beta 1 Monoclonal antibody
TGF beta 1 Monoclonal Antibody for
Host / Isotype
Mouse / IgG1
Reactivity
Human
Applications
Conjugate
CoraLite® Plus 488 Fluorescent Dye
CloneNo.
1E3E9
验证数据展示
Planning an IHC experiment? We recommend our IHCeasy TGF beta 1 Ready-To-Use IHC Kit. TGF beta 1 primary antibody included.
For other applications, we recommend the unconjugated version of this antibody, 69012-1-Ig
产品信息
CL488-69012 targets TGF beta 1 in applications and shows reactivity with Human samples.
| Tested Applications | Application Description |
| Tested Reactivity | Human |
| Immunogen | TGF beta 1 fusion protein HZ-1011 种属同源性预测 |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Full Name | transforming growth factor, beta 1 |
| Synonyms | CED, DPD1, LAP, NeutraKine® TGF beta 1, TGF ?1, TGF beta 1, TGFB, TGFB1, TGFbeta, TGF-beta1 |
| Gene Symbol | TGFB1 |
| Gene ID (NCBI) | 7040 |
| Conjugate | CoraLite® Plus 488 Fluorescent Dye |
| Excitation/Emission Maxima Wavelengths | 493 nm / 522 nm |
| Form | Liquid |
| Purification Method | Protein G purification |
| Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| Storage Conditions | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
TGFB, also named as LAP and TGFB1, is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for it. TGFB positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. It is highly expressed in bone. Mutation of TGFB are the cause of Camurati-Engelmann disease (CED) which known as progressive diaphyseal dysplasia 1 (DPD1).
