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TGFBR1 Recombinant antibody, PBS Only

TGFBR1 Uni-rAbTM Recombinant Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241441A11

Cat no : 84453-1-PBS

Print datasheet

Synonyms

Activin receptor-like kinase 5, Activin receptor like kinase 5, Activin A receptor type II-like protein kinase of 53kD, AAT5, 241441A11

验证数据展示

  • WB analysis using 84453-1-RR (same clone as 84453-1-PBS)

    WB analysis using 84453-1-RR (same clone as 84453-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84453-1-RR (TGFBR1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84453-1-PBS in a different storage buffer formulation.

  • IHC staining of human placenta using 84453-1-RR (same clone as 84453-1-PBS)

    IHC staining of human placenta using 84453-1-RR (same clone as 84453-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 84453-1-RR (TGFBR1 antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84453-1-PBS in a different storage buffer formulation.

  • IHC staining of human lung cancer using 84453-1-RR (same clone as 84453-1-PBS)

    IHC staining of human lung cancer using 84453-1-RR (same clone as 84453-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 84453-1-RR (TGFBR1 antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84453-1-PBS in a different storage buffer formulation.

  • IHC staining of human lung cancer using 84453-1-RR (same clone as 84453-1-PBS)

    IHC staining of human lung cancer using 84453-1-RR (same clone as 84453-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 84453-1-RR (TGFBR1 antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84453-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84453-1-RR

    Affinity and Kinetic Characterization of 84453-1-RR

    Biolayer interferometry (BLl) kinetic assays of 84453-1-RR against Human TGFBR1 were performed. The affinity constant is 67.5 pM.

产品信息

84453-1-PBS targets TGFBR1 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications WB, IHC, Indirect ELISA Application Description
Tested Reactivity human
Immunogen TGFBR1 fusion protein Ag31620 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name transforming growth factor, beta receptor 1
Synonyms Activin receptor-like kinase 5, Activin receptor like kinase 5, Activin A receptor type II-like protein kinase of 53kD, AAT5, 241441A11
Calculated Molecular Weight56KD
Observed Molecular Weight56 kDa
GenBank Accession NumberNM_004612
Gene Symbol TGFBR1
Gene ID (NCBI) 7046
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDP36897
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TGFBR1 (TGF-beta receptor type-1) encodes a serine/threonine kinase receptor for transforming growth factor-beta. TGFB1, TGFB2 and TGFB3 signals are transduced from the cell surface to the cytoplasm and regulate lots of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Mutations in both TGFBR2 and TGFBR1 were associated with early onset and aggressive thoracic aortic disease with MFS-like skeletal features, but also hypertelorism, craniosynostosis, developmental delay, cleft palate and bifid uvula, congenital heart disease and aneurysms, and dissections throughout the arterial tree with marked arterial tortuosity (PMID: 15731757, PMID: 27879313).